This is the SELECT Participant Website.
This is a website for SELECT participants. Participants can access MySELECTData, a secure web application, that allows SELECT participants to review and submit their study data online.
This website and MySELECTData are shut down for maintenance each week on Saturday evenings between 8:00pm and 9:00pm Pacific Time. If you are unable to access this website or MySELECTData outside of the maintenance time, please try again later. If you experience repeated access problems with the site please contact the Coordinating Center.
SELECT News
We have some very important information to share with SELECT participants.
In 2008, we reported that the vitamin E and selenium study supplements did not prevent prostate cancer. The results also showed a slight increase in prostate cancer risk for those men taking vitamin E alone. However, this finding was not statistically significant and the evidence at that time suggested that the increased risk may have been due to chance. We also found that selenium might increase the chance of getting diabetes, although this may also have been due to chance.
Now, with additional information and longer follow-up, the Data and Safety Monitoring Committee has found that participants who took the study supplements of vitamin E (400 IU per day) and a placebo for selenium have a 17% higher risk of prostate cancer than those who took two placebos. Another way to explain this is that for every 1000 participants who were given study supplements for five years and then followed for an additional two years, we would observe 65 prostate cancers in the placebo group, and 76 in the vitamin E alone group. With further follow-up, this observation is now a statistically significant finding. This means it is unlikely that this increase in risk is due to chance. Those participants who took the study supplements of selenium and a placebo for vitamin E, or selenium and vitamin E, or two placebos, do not have a higher risk of prostate cancer.
Almost all of the prostate cancers diagnosed in men on SELECT, including those participants on vitamin E, were early stage. Participants who took any study supplements had no increase or decrease in the risk of other cancers or death. And we no longer see an increased risk of diabetes in participants who took selenium.
For answers to other questions about SELECT please go to the National Cancer Institute Frequently Asked Questions:
http://www.cancer.gov/newscenter/qa/2008/selectqa
SELECT results articles from the Journal of the American Medical Association (JAMA):
Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT), JAMA 2011; 306(14) 1549-1556.
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers, December 9 2008
Letters to SELECT Participants
2011 - Letter to Participants in SELECT Centralized Follow-up (CFU): English, Spanish
Study Sites may have sent a similar letter to participants who are not on Centralized Follow-up
Previous Study Results Information
2008 - Letter to SELECT Participants regarding stopping study supplements: English, Spanish, French
2005 - Letter to SELECT Participants regarding study results for HOPE-TOO: Heart Outcomes Prevention Evaluation -- The Ongoing Outcomes (HOPE-TOO): English, Spanish, French
2004 - Letter to SELECT Participants regarding study results on selenium, skin cancer and the Prostate Cancer Prevention Trial (PCPT): English, Spanish, French
If you are a study participant and you want to know what study supplements you were taking, please contact us.
This page was last updated on 12/30/2011.
